Data for 148 SUNDS victims and 444 controls (matched 1:3 on sex, race, and age of death within 1 year) were collected from Sun Yat-sen University from January 1, 1998, to December 31, 2014, to search morphological changes. Approximately The absence of clinic information including ECG data is always a study limitation that is inherent to the vast majority of investigations on postmortem cases, especially with SUNDS victims where by their very definition are apparently healthy individuals who die suddenly and unexpectedly. as SUDS based on additional information. Rare non-synonymous variants were characterized according to the strict variant interpretation guidelines outlined by the American College of Medical Genetics (ACMG).22 To be considered pathogenic or likely pathogenic, the variant must first be absent among all aforementioned control population databases. median Although Brugada syndrome affects both men and women, the condition appears to be 8 to 10 times more common in men. Nakajima K, Takeichi S, Nakajima Y, Fujita MQ. In this video we cover the Brugada Syndrome ECG changes and Brugada Syndrome Pathophysiology, as well as. Postmortem molecular analysis of KCNQ1, KCNH2, KCNE1 and KCNE2 genes in sudden unexplained nocturnal death syndrome in the Chinese Han . remains unknown. Nine were Laotian (five Hmong, two lowland Lao, and two The https:// ensures that you are connecting to the for Cardiology. Pathological characteristics of Pokkuri death syndrome; narrow circumferences of the coronary arteries in Pokkuri death syndrome cases. Arizona, 1983;250:29472951. "Pokkuri" means suddenly and unexpectedly in Japanese, and Pokkuri Death Syndrome (PDS) refers to an unexplained type of SCD in Japan with unknown cause. Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Brugada syndrome: an update. In. Tavora F, Zhang Y, Zhang M, et al. Brugada syndrome is a condition that causes a disruption of the heart's normal rhythm. To use the sharing features on this page, please enable JavaScript. How can gene variants affect health and development? sudden unexplained nocturnal death syndrome (sunds) has gained attention all over the world since it was first reported in 1917. Sudden Unexplained Nocturnal Death Syndrome in Central : Medicine in patients with sudden cardiac death. Genetic and biophysical basis of sudden unexplained nocturnal death Association of common and rare variants of SCN10A gene with sudden unexplained nocturnal death syndrome in Chinese Han population. of 2005 The Target Captured Next Generation sequencing for 80 genes associated with arrhythmia/cardiomyopathy were performed in 44 SUNDS victims and 17 BrS patients to characterize the molecular spectrum. unknown), and two each were Vietnamese and Kampuchean. remains similar to that of previously reported cases (Table 1) (1). 2017 Jan;131(1):53-60. doi: 10.1007/s00414-016-1397-1. DC: Department of State, Refugee Program, Sept. 1987. In the 1960s, some 40,000 ethnic Hmong were recruited to fight Vietcong incursions into Laos. The genetic etiology of SUNDS has been focused on BrS which reportedly shares the type 1-BrS ECG pattern with about 60% of survived SUNDS patients.2,34 The SCN5A gene is the most common BrS-susceptibility gene accounting for 2030% of the disorder. PMC 1SS): 43SS-53SS. Only 2 of 44 SUNDS cases compared with 5 of 17 patients with BrS hosted a rare variant in the most common BrS-causing gene, SCN5A (P=.01). The condition, also known as sudden unexplained nocturnal death syndrome or the "moaning death," is commonly caused by a mutation in the SCN5A gene, which is responsible for forming sodium channels and maintaining normal heart rhythm by facilitating the transportation of positively charged sodium atoms into the heart muscle. Drugs that can induce an altered heart rhythm include medications used to treat some forms of arrhythmia, a condition called angina (which causes chest pain), high blood pressure, depression, and other mental illnesses. Epub 2017 Feb 25. Mutations in the SCN5A gene alter the structure or function of the channel, which reduces the flow of sodium ions into cells. JAMA 1983;250:2947-51. Identification of Novel SCN5A Single Nucleotide Variants in Brugada Syndrome: A Territory-Wide Study From Hong Kong. Conclusion: Nonischemic left ventricular scar and cardiac sudden death in the young. The victim has no known antecedent illnesses, and there are no factors that might precipitate cardiac arrest. in the first 4 months of 1988. Bookshelf The principles outlined in the Declaration of Helsinki were followed. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. 2021 Aug 5;8:714844. doi: 10.3389/fcvm.2021.714844. The .gov means its official. and Nakajima K, Takeichi S, Nakajima Y, Fujita MQ. Increasing evidence has shown that cardiomyopathy shares some common susceptibility genes (SCN5A, PKP2, RYR2, ABCC9) with primary arrhythmia disorders (BrS, AF).37,38 Recently, the rare variants in cardiomyopathy causing genes CASQ2, DSG2, JUP, and DSP were identified to be potentially associated to BrS.17,39 The yield of rare variants in the 48 cardiomyopathy-associated genes in both BrS and SUNDS in this study highlights again the increasingly recognized potential intrinsic linkage between cardiomyopathy and primary arrhythmia with apparently normal heart. CONTACT Sudden death typically occurs around age 40. Informed consent was obtained from the patients or legal representatives of the victims. 36,000 in 1987 (4,5). 1 the syndrome is featured by predominance of healthy young males without significant medical history, who suddenly die during sleep. (1) These deaths involved relatively young previously healthy persons. Brugada R, Campuzano O, Sarquella-Brugada G, Brugada P, Brugada J, Hong K. Please enable it to take advantage of the complete set of features! Molecular diagnostics of cardiovascular diseases in sudden unexplained death. Sudden Unexpected Nocturnal Death Syndrome (SUNDS) - DoveMed Brugada syndrome can be caused by mutations in one of several genes. Using the strict American College of Medical Genetics guideline-based definition, it was found that only 2 of 44 (KCNQ1) SUNDS and 3 of 17 (SCN5A) patients with BrS hosted a "(likely) pathogenic" variant. Tester DJ, Ackerman MJ. Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma Sudden unexplained death in Asian immigrants: Recognition of a syndrome Health and Injury Control, CDC, telephone: (404) 488-4780. this -, Nakajima K, Takeichi S, Nakajima Y, Fujita MQ. arrhythmia; sudden cardiac death; sudden death; sudden unexplained nocturnal death syndrome. What is Nocturnal death Syndrome? - Aquarius Age The functionality is limited to basic scrolling. A total of 80 genes associated with primary arrhythmia- and cardiomyopathy-related disorders were investigated as we described previously.17 More than 94% of the target base pairs (exon and 10bp of adjacent introns) were covered at least 10. Association of common variants in NOS1AP gene with sudden unexplained nocturnal death syndrome in the southern Chinese Han population. 148 SUNDS victims and 444 controls (matched 1:3 on gender, race, and age of death within 1 year) were collected from Sun Yat-sen University from January 1, 1998 to December 31, 2014 to search morphological changes. Sudden Unexpected Nocturnal Death Syndrome Since 1977 more than a hundred Southeast Asian immigrants in the United States have died from the mysterious disorder known as sudden unexpected nocturnal death syndrome (SUNDS). Accessibility syndrome. length of time in the United States for the 88 of the 117 decedents The thymus is a vestige with prominent atrophy in the adult. 2017 May;131(3):621-628. doi: 10.1007/s00414-016-1516-z. Deeper on-going investigations on morphological, molecular pathological, and electrophysiological characteristics in larger SUNDS cohorts to address the etiology and mechanism of sudden death may contribute to the increasingly important precision medicine for SCD.40,41. Notably, the present study has strongly suggested that the molecular pathological spectrum for SUNDS may be much broader than BrS. Bethesda, MD 20894, Web Policies The number of All but one were male and all died at night. INTRODUCTION. Since 1982, the number of SUDS cases has Only genetic rare variants leading to non-synonymous amino acid changes (missense, nonsense, frame-shift insertion/deletions, in-frame insertion/deletions, or splice-errors) and with a minor allele frequency (MAF) <.01 observed in any ethnic group among four population databases including the National Heart, Lung and Blood Institute Grand Opportunity (NHLBI GO) Exome Sequencing Project (n=6,503), the 1,000 Genome Project (n=2,504), Exome Aggregation Consortium (ExAC, n=60,706 all ethnicities, n=4,327 East Asian) and a local database (n=2,087, 989 of whom were Chinese, with normal phenotype) were considered for further analysis. were men. Some controls had primary acute violent injuries associated with their cause of death such as electrical injury marks on the skin and muscular contusion. Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected cardiac arrest in young adults, usually at night during sleep. Diabetic Dead-in-Bed Syndrome: A Possible Link to a Cardiac Ion Methods: An additional 17 patients with Brugada syndrome (BrS) collected from January 1, 2006, to December 31, 2014, served as a comparative disease cohort. Culture & Lifestyle, Psychism Sleeping with the Dark Entities. Association of common and rare variants of SCN10A gene with sudden Targeted next generation sequencing revealed a novel deletion-frameshift mutation of KCNH2 gene in a Chinese Han family with long QT syndrome: A case report and review of Chinese cases. Refugee Resettlement Program. 2 The disease is termed "Bangungut" in Philippines, 1 "Lai Tai" in Thailand, 2 "Pokkuri Death Syndrome" in . Careers. Various hypotheses, such as bacterial infection,10 potassium deficiency,11 structural or functional abnormalities of the coronary arteries,3 and nocturnal sleep respiratory disorders,7 have been postulated by epidemiological studies on SUNDS but need further confirmation.4,9 While structural diseases such as cardiac conduction system (CCS) abnormalities and acute hemorrhagic pancreatitis account rarely for the death of a SUNDS victim,13,59 the vast majority of cases reported were defined as autopsy-negative.1,3,4,79,1215. Night terrors and sudden unexplained nocturnal death Sudden Unexpected Death in Epilepsy (SUDEP) | CDC In addition, three earlier reports were confirmed as SUDS based on additional information. Sudden Unexplained Nocturnal Death Syndrome: Bangungot . Generating an ePub file may take a long time, please be patient. Persons using assistive technology might not be able to fully access information in this file. Aug;2(8):905. In this model, we set a supposed, MeSH 1;11(3):337-45. The remaining rare variants were categorized as variants of uncertain significance (VUS). Back from the dead: How one man survived sudden death syndrome This may limit a more precise assessment of normalized organ weight. V, Duboscq-Bidot L, Daumy X, Simonet F, Teusan R, Baron E, Violleau J, Persyn E, [Research Progress of the Relationship between SUNDS and OSAHS]. Proteins produced by other genes involved in the condition form or help regulate ion channels that transport calcium or potassium into or out of heart muscle cells. He was Authors Jingjing Zheng 1 , Da Zheng 1 , Terry Su 1 , Jianding Cheng 2 Affiliations 1 Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Other cases may result from new mutations in the gene. Nat Clin Pract Cardiovasc Med. Brugada R, Brugada J, Veerakul G, Li H, Bowles NE, Brugada P, Antzelevitch C, It is Sudden Unexplained Nocturnal Death Syndrome. The ePub format uses eBook readers, which have several "ease of reading" features Tse G, Lee S, Liu T, Yuen HC, Wong ICK, Mak C, Mok NS, Wong WT. Pokkuri Death Syndrome; sudden cardiac death cases without coronary atherosclerosis in South Asian young males. doi: 10.1097/MD.0000000000019749. Does sudden unexplained nocturnal death syndrome remain the autopsy CDC. These findings suggest the possibility that cardiomyopathy-susceptibility gene variants may contribute to lethal arrhythmia of SUNDS, and suggest this gene pool may be expected to yield additional novel genetic causes for SUNDS and BrS. Genetic Testing Registry: Brugada syndrome, Genetic Testing Registry: Brugada syndrome 1, National Organization for Rare Disorders (NORD). sharing sensitive information, make sure youre on a federal Juang JM, Huang SK. 25;101(2):173-8. Review. F, Schmitt S, Bzieau S, Le Marec H, Dina C, Schott JJ, Probst V, Redon R. and Health Effects, Center for Environmental Health and Injury Summary. What is the prognosis of a genetic condition? Chokevivat V, Warintrawat S, Choprapawan C. Epidemiology of Lai Tai in Thailand. ABOUT MMWR | September 26, 2011. The collected autopsy findings included gender, age, height, time of death, the investigation record of death scene, and the macroscopic and microscopic examinations of vital organs. 2014 Mar;236:38-45. doi: 10.1016/j.forsciint.2013.12.033. The most commonly mutated gene in this condition is SCN5A, which is altered in approximately 30 percent of affected individuals. At autopsy, no cause of death can be identified in the heart, lung, or brain. 2006 Mar;8(3):143-55. Review. The 13 new cases occurred in nine states. These results prompt speculation that rare variants in cardiomyopathy-related genes may have a slight but actual impact on cardiac morphological changes which may contribute to primary or secondary arrhythmia in SUNDS. Copyright 2016 Mayo Foundation for Medical Education and Research. for Future Cardiol. Hayashi M, Shimizu W, Albert CM. The definition of SUNDS described a perplexing entity with special clinic phenotype:19 (1) predominantly occurs in Southeast Asia or immigrants from Southeast Asia without a significant disease history; (2) prevails preponderantly in apparently healthy males (>90%); (3) >80% of victims are at the ages between 2040; (4) occurs during nocturnal sleep with typical symptoms such as moaning and tachypnea which last for just a few minutes prior to death; (5) there is no pathological changes to identify the cause of death; (6) most victims were sporadic; (7) death most frequently occurred out of hospital without any clinical record, giving first access to forensic pathologists rather than the clinicians. Michaud K, Grabherr S, Faouzi M, Grimm J, Doenz F, Mangin P. Pathomorphological and CT-angiographical characteristics of coronary atherosclerotic plaques in cases ofsudden cardiac death. Sudden Unexplained Nocturnal Death Syndrome in Central China (Hubei 1-4 The victims are healthy and die during sleep, following agonal respiration. Notably, we observed that these rare variants were associated with altered heart structure and a tendency for earlier average age at death by approximately 5 years. The https:// ensures that you are connecting to the The inclusion criteria for SUNDS were as previously reported:4,9,1215 (1) an apparently healthy individual older than 15 years and without a history of significant disease; (2) who died of a sudden unexpected death during nocturnal sleep; (3) and had a negative autopsy, toxicology, histology, and death-scene investigation that resulted in their death being unexplained. "Pokkuri" means suddenly and unexpectedly in Japanese, and Pokkuri Death Syndrome (PDS) refers to an unexplained type of SCD in Japan with unknown cause. Epub 2019 Dec 10. It is prevalent in Southeast Asia, colloquially called Bangungut (Philippines), Pokkuri (Japan) and Lai-tai (Thailand). Most are young men (35.97.8 years). By the 1980's SUNDS was the chief cause of death in Southeast Asian refugee camps across the United States. Is sudden unexplained nocturnal death syndrome in Southern China a A case control study on autopsy findings in sudden unexplained nocturnal death syndrome. 8600 Rockville Pike government site. Crotti L, Marcou CA, Tester DJ, et al. sudden unexplained nocturnal death Idiopathic death often in young, previously healthy, Southeastern Asian , attributed to a conduction system anomaly coupled with 'culture shock' and relocation-related stress in emigrants. 2017 Feb;33(1):52-57. doi: 10.3969/j.issn.1004-5619.2017.01.013. J Am Coll Cardiol. However, using the strict ACMG guideline-based definition for pathogenicity, only 2/44 SUNDS cases hosted a likely pathogenic variant (p.Q376sp-KCNQ1, p.G626_P631del-KCNQ1) compared to 3/17 patients with BrS that hosted either a pathogenic or likely pathogenic variant (p.G400R-SCN5A, p.D1275N-SCN5A, T1893Pfs*29-SCN5A ; Table 3). continued to decline (Figure 1). The project was approved for human research by the ethics committee of Sun Yat-sen University. 2005 Apr;2(4):429-40. Review. HHS Vulnerability Disclosure, Help 2017 Apr 3;6(4):e005330. and 2004;101(4):157-69. Interestingly, April and January, and 3:00 to 6:00 AM were the peak months and times of death. Mayo Clin Proc. DePristo MA, Banks E, Poplin R, et al. Cardiac arrhythmia has been proposed as the factor responsible for such deaths. 2021 May;18(5):778-784. doi: 10.1016/j.hrthm.2020.12.035. No significant differences in the average left and right ventricular thickness were found between the two groups. Author manuscript; available in PMC 2017 Nov 1. online-only references in the Supplements, catecholaminergic polymorphic ventricular tachycardia, sudden unexplained nocturnal death syndrome. These 13 reports bring the Mayo Clin Proc. Monthly summary, December 31, 1987. Fibrosis, Connexin-43, and conduction abnormalities in the Brugada syndrome. Epub 2016 Aug 25. that a structural abnormality of the cardiac conduction system (6) Elfawal MA. Spectrum and prevalence of mutations involving BrS1-through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing. genes in a cohort of unrelated patients referred for Brugada syndrome genetic Vinculin (VCL) was linked to sudden arrhythmia death in VCL knockout mice prior to . the phenomenon of sudden unexplained nocturnal death in patients without known cardiac disease has been examined for more than a century. Desire Press: 1993;3850. SUNDS and BrS may result from different molecular pathological underpinnings. Sudden unexplained nocturnal death among Southeast Asians Since July 1977 at least 96 cases of SUNDS occurring in Southeast Asian refugees have been reported to the Center for Disease Control (CDC). Update: Sudden Unexplained Death Syndrome Among Southeast Asian Re fugees -- United States Between October 1, 1986, and April 30, 1988, 10 cases of sudden unexplained death syndrome (SUDS) in Southeast Asian (SEA) refugees were reported to CDC. Burdine RD, Preston CC, Leonard RJ, Bradley TA, Faustino RS. The categorical variables were evaluated using the Pearson Chi-square test or Fishers exact test, with OR (95% CI) given afterwards if appropriate. Peters S. Ion channel diseases as a part in the definition and classification of cardiomyopathies recently confirmed in Brugada syndrome. Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy government site. 2005 rate of SUDS deaths in 1988 will probably remain at 4-5 deaths and Impact of Obstructive Sleep Apnea On In-Hospital Outcomes in Patients With Atrial Fibrillation: A Retrospective Analysis of the National Inpatient Sample. He had an episode of syncope few months prior to his death but he did not seek medical attention. See our, URL of this page: https://medlineplus.gov/genetics/condition/brugada-syndrome/. Demographics of SUNDS victims and controlsa, The rare variants identified in primary arrhythmia or cardiomyopathy susceptible genes in SUNDS victimsa,b,c, The rare variants identified in primary arrhythmia or cardiomyopathy susceptible genes in Brugada syndrome patientsa,b, Does sudden unexplained nocturnal death syndrome remain the autopsy negative disorder: a gross, microscopic, and molecular autopsy investigation in Southern China, GUID:A9D7F8DD-921E-483C-AAA6-674B19C9EDB0, Department of Forensic Pathology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China (Zhang, Zheng, Tang, Cheng); Departments of Cardiovascular Diseases (Division of Heart Rhythm Services), Pediatrics (Division of Pediatric Cardiology), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, USA (Tester, Ackerman); BGI-Shenzhen, Shenzhen, China (Gao, Liu); Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (Chen); Department of Pathology and Laboratory Medicine and Waisman Center, University of Wisconsin, Madison, USA (Corliss); Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, USA (Lang, Kyle, Makielski), The publisher's final edited version of this article is available at, sudden unexplained nocturnal death syndrome, arrhythmia, Brugada syndrome, cardiomyopathy, genetic, Demographics of SUNDS victims and controls, The rare variants identified in primary arrhythmia or cardiomyopathy susceptible genes in SUNDS victims, The rare variants identified in primary arrhythmia or cardiomyopathy susceptible genes in Brugada syndrome patients. The site is secure. An official website of the United States government. Federal government websites often end in .gov or .mil. An East Asian Common Variant Vinculin P.Asp841His Was Associated With Sudden Unexplained Nocturnal Death Syndrome in the Chinese Han Population. Between October 1, 1986, and April 30, 1988, 10 cases of sudden These controls represented individuals with an acute non-disease death within 24 hours caused by traffic accident, mechanical asphyxia, electric shock, and carbon monoxide poisoning and were previously healthy, without any significant disease or pathological changes identified by postmortem examinations. Sudden unexplained death syndrome in Southeast Asian Brgdar A, Yi J, Awan A, Taha M, Ogunti R, Gharbin J, Prafulla M, Opoku I. Cureus. H, Wilde A. Brugada syndrome: report of the second consensus conference. Moreover, only 2/44 (4.5%) SUNDS cases compared to 5/17 (29.4%, P=.01) BrS patients hosted at least one rare variant in the most common BrS causing gene SCN5A. for Sudden unexplained nocturnal death syndrome (SUNDS) is a condition characterized by unexpected cardiac arrest in young adults, usually at night during sleep. Sudden unexpected nocturnal death syndrome in the Mariana islands. DOWNLOADS | A comparison of genetic findings in sudden cardiac death victims and cardiac patients: the importance of phenotypic classification. resuscitated but was comatose when hospitalized; his condition deaths occurred either at night or during sleep. Death often occurs 3 to 4 hours after sleep onset, and witnesses have observed choking, gasping, groaning, gurgling, frothing at the mouth, labored breathing without wheezing or stridor . Sudden Unexpected Nocturnal Death Syndrome - The Order of the Good Death Forensic and clinical pathologists have attempted to uncover plausible pathogenic morphological characteristics underlying SUNDS for nearly a century.13 Several pilot autopsy studies have suggested some cardiac structure changes in SUNDS: Kirschner (1986),23 Park (1990),24 and Elfawal (2000) et al25 observed cardiomegaly or cardiac hypertrophy in 14 of 18 SUNDS cases (all with CCS anomalies), 4 of 14 SUNDS decedents (without grossly detectable structural cardiac anomaly), 7 of 22 SUNDS victims (2 cases had coronary stenosis, 7 had cardiac hypertrophy), respectively. Postmortem long QT syndrome genetic testing for sudden unexplained death in the young. total number of SUDS in SEA refugees to 117 since CDC surveillance The ePub format is best viewed in the iBooks reader. 2016 Dec;58:78-89. doi: 10.1016/j.humpath.2016.08.004. Target-captured next-generation sequencing for 80 genes associated with arrhythmia/cardiomyopathy was performed in 44 SUNDS victims and 17 patients with BrS to characterize the molecular spectrum. J Am Coll Cardiol. Cardiovasc Pathol. The average circumferences of all cardiac valves in SUNDS tended to be increased and the mitral valves were significantly increased compared to controls (Figure 1A), which is consistent with the slight increase in average heart weight, and confirming a slightly enlarged heart size in SUNDS. In addition, we conducted a next-generation sequencing based 80 genes targeted analysis on consecutive 44 SUNDS victims and 17 BrS patients to characterize the molecular pathological spectrum of Chinese SUNDS compared to BrS. Additional 17 Brugada syndrome (BrS) patients collected from January 1, 2006 to December 31, 2014 served as a comparative disease cohort. After normalization, only average heart weight in SUNDS showed a significant increase compared to controls (P =.04, Supplemental Table 1 in the Supplement). J Mol Cell Cardiol. Vatta M, Dumaine R, Varghese G, et al. Sudden unexplained nocturnal death syndrome (SUNDS) is a genetic disorder that can cause sudden death in young and healthy adults during sleep at night. Do vengeful spirits or evil forces cause nightmares, sleep paralysis, or psychic paralysis? Tag: sudden unexplained nocturnal death syndrome. Kirschner RH, Eckner FA, Baron RC. Hum Mol Genet. Considering the latent cardiac structural abnormality identified in this study, we then focused on the rare variants in 48 genes previously associated with cardiomyopathy such as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular cardiomyopathy and left ventricular noncompaction. the Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, decline in newly arrived SEA refugees, since most deaths occur Can You Really Die in Your Nightmares? | Live Science Objective: (A) 148 SUNDS cases showed statistically significant increased circumferences of cardiac valves versus 444 controls. The distinct association between cardiomyopathy-related rare variants and SUNDS warrants further investigation. 2005 Sudden death among Southeast Asian refugees. Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma [3] [4] The syndrome is rare in most areas around the world but occurs in populations that are culturally and genetically distinct. Using the strict American College of Medical Genetics guideline-based definition, only 2/44 (KCNQ1) SUNDS and 3/17 (SCN5A) BrS patients hosted a (likely) pathogenic variant. and transmitted securely. Although the present study was the largest Chinese SUNDS autopsy case series to characterize the morphological changes and the primary genetic spectrum, the relatively small sample size for genetic testing as well as the lack of clinic records including ECG and genetic screening of family members limited a deeper analysis of association between clinical phenotype, morphological changes and genetic findings. The controls were matched 3:1 with the SUNDS cases. These syndromes may be one of the many conditions that fall. This future database will benefit us for accurately understanding the pathogenesis of SUNDS. Sudden arrhythmic death syndrome ( SADS) is a sudden unexpected death of adolescents and adults, mainly during sleep. Looking for abbreviations of SUNDS? Sudden unexplained nocturnal death syndrome - Wikipedia
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