However, because of the lack of specificity, alternative affinity columns based on AAV-specific binding proteins such as scFvs and antibody single domains from llamas (camelids) have started to dominate the field. AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro. CMVs are characterized by large DNA genomes and typically asymptomatic infection in healthy hosts. 206. Zhang Y,Zhou X,Cheng L,Wang X,Zhang Q,Zhang Y,Sun S, 895. Zhong-Fan Ruan,Ming Xie,Shu-Jia Gui,Fang Lan,Juan Wan,Yan Li, 1411. Whole exome analysis reveals the genomic profiling related to chemo-resistance in Chinese population with limited-disease small cell lung cancer. Kai Wang,Jianbao Zheng,Junhui Yu,Yunhua Wu,Jing Guo,Zhengshui Xu,Xuejun Sun, 1233. Jin H, Ma S, Song B, Ma L, Pi J, Chen X, Chen Y, Cai J. Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF- signaling pathway. 185. Liu X, Zhang B, Guo Y, Liang Q, Wu C, Wu L, Tao K, Wang G, Chen J. PAX3 is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Wang Q, Shen L, Huang W, Song Y, Xiao L, Xu W, Liu Y. Plays a key role MicroRNA-96 expression induced by low-dose cisplatin or doxorubicin regulates chemosensitivity, cell death and proliferation in gastric cancer SGC7901 cells by targeting FOXO1. 258. Li Y,Huang J,Zeng B,Yang D,Sun J,Yin X,Lu M,Qiu Z,Peng W,Xiang T,Li H,Ren G, 431. He H, Yang T, Jia S, Zhang R, Tu P, Gao J, Yuan Y, Han W, Yu Y. miR-496 remedies hypoxia reoxygenation-induced H9c2 cardiomyocyte apoptosis via Hook3-targeted PI3k/Akt/mTOR signaling pathway activation. Subtle differences in sugar-binding preferences, encoded in capsid sequence differences, can influence cell-type transduction preferences of the various AAV variants [3133]. tRNA-derived fragment tRF-03357 promotes cell proliferation, migration and invasion in high-grade serous ovarian cancer. 172. Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats. BRG1 expression is increased in human glioma and controls glioma cell proliferation, migrationand invasion in vitro. The aap gene encodes the assembly-activating protein (AAP) in an alternate reading frame overlapping the cap gene. Zhenyu Zhu,Qingsheng Hou,Hongliang Guo, 1492. Xu L,Liu F,Li C,Li S,Wu H,Guo B,Gu J,Wang L, 1010. Liu X, Zhang B, Guo Y, Liang Q, Wu C, Wu L, Tao K, Wang G, Chen J. Synthesis, Photothermal Effect and Cytotoxicity of FeO@Au Nanocomposites, Interleukin-35 Dampens CD8 + T Cells Activity in Patients With Non-viral Hepatitis-Related Hepatocellular Carcinoma. Addepalli Y,Yang X,Zhou M,Reddy DP,Zhang SL,Wang Z,He Y, 394. Ren Z,Chen L,Wang Y,Wei X,Zeng S,Zheng Y,Gao C,Liu H, 573. HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer. Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation. Lanthanum citrate induces anoikis of Hela cells. As a result of these subtle variations in primary and secondary receptor interactions for the various AAV variants, one can choose a variant that possesses a particular tropism and preferentially infects one cell or tissue type over others (Table1). Tissue-specific codon usage and the expression of human genes. Tan J,Sun T,Shen J,Zhu H,Gong Y,Zhu H,Wu G, 806. LncRNA TUG1 mediates lipopolysaccharide-induced proliferative inhibition and apoptosis of human periodontal ligament cells by sponging miR-132. Lulu Li,Li Xu,Si Wen,Ying Yang,Xin Li,Qiuling Fan, 1340. miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression. LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure. Cytotoxicity of different sized TiO2 nanoparticles in mouse macrophages. C1q/tumor necrosis factor-related protein-3-engineered mesenchymal stromal cells attenuate cardiac impairment in mice with myocardial infarction. Guo Chen,Zhi-Duan Cai,Zhuo-Yuan Lin,Cong Wang,Yu-Xiang Liang,Zhao-Dong Han,Hui-Chan He,Ru-Jun Mo,Jian-Ming Lu,Bin Pan,Chin-Lee Wu,Fen Wang,Wei-de Zhong, 1374. Kotterman MA, Schaffer DV. Zhong L, Li B, Mah CS, Govindasamy L, Agbandje-McKenna M, Cooper M, et al. Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3 signaling pathway. RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer. Lu Yang,Hongwei Sun,Xing Liu,Jinxin Chen,Zhimin Tian,Jia Xu,Bowen Xiang,Baoli Qin, 1099. Guoning Zhang,Mengzhen Gu,Yingjia Xu,Zongming Wu, 1176. Salmon F, Grosios K, Petry H. Safety profile of recombinant adeno-associated viral vectors: focus on alipogene tiparvovec (Glybera. [25], Cell-penetrating peptides (CPPs), also known as peptide transduction domains (PTDs), are short peptides (< 40 amino acids) that efficiently pass through cell membranes while being covalently or non-covalently bound to various molecules, thus facilitating these molecules' entry into cells. Amelioration of whole abdominal irradiation-induced intestinal injury in mice with 3,3'-Diindolylmethane (DIM). Antioxidant action and protective and reparative effects of lentinan on oxidative damage in HaCaT cells. Long noncoding RNA DLX6-AS1 promotes breast cancer progression via miR-505-3p/RUNX2 axis. Ge S,Mrozik KM,Menicanin D,Gronthos S,Bartold PM. miRNA-10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism. Effects ofa novel photoactivated photosensitizer on MDR1 over-expressing human breastcancer cells. Dai W,Dong P,Liu J,Gao Y,Hu Y,Lin H,Song Y,Mei Q, 667. Qin T,Lu XT,Li YG,Liu Y,Yan W,Li N,Sun YY, 424. Kuang Y,Hu B,Feng G,Xiang M,Deng Y,Tan M,Li J,Song J, 1136. Pi L, Zhu G, She L, Wei M, Liu G, Chen C, Hu D, Peng F, Tan H, Liu Y, Huang D, Tian Y, Zhang X. These programs are at various stages of development, with the most advanced for X-linked retinoschisis and achromatopsia in phase I safety studies (http://www.AGTC.com) (Table3). Other methods involve mixing other viral vectors with cationic lipids or hybridising viruses. Zhang Y, Wang Z, Chen M, Peng L, Wang X, Ma Q, Ma F, Jiang B. Hao Xu,Shangjun Wu,Xin Shen,Ding Wu,Zhenguo Qin,Hao Wang,Xiaogang Chen,Xiaoqing Sun, 1075. Tang H,Long Q,Zhuang K,Yan Y,Han K,Guo H,Lu X, 1270. Parbeen Singh,Li Wu,Xiaohong Ren,Wei Zhang,Yan Tang,Yongli Chen,Andrew Carrier,Xu Zhang,Jiwen Zhang, 1353. Colchicine causes prenatal cell toxicity and increases tetraploid risk. Long noncoding RNA OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAAT/PI3K/AKT/mTOR signaling pathway by sponging the miR-340-5p. This will eventually result in the loss of the transgene and transgene expression, with the rate of transgene loss dependent on the turnover rate of the transduced cell. Wei Lie Mo,Jing Ting Jiang,Luo Zhang,Qi Cheng Lu,Jing Li,Wei Dong Gu,Yun Cheng,Hai Tao Wang, 1156. Wang YP,Liu J,Liu D,Wang XD,Bian AM,Fang DZ,Hui XB, 945. Jiang SL, Pan DY, Gu C, Qin HF, Zhao SH. Induction of pro-viral grass carp Ctenopharyngodon idella Hsp70 instead of Hsc70 during infection of grass carp reovirus. Peng X,Li X,Li C,Yue S,Huang Y,Huang P,Cheng H,Zhou Y,Tang Y,Liu W,Feng D,Luo Z, 800. Yu XN,Guo HY,Liu TT,Zhang GC,Zhu HR,Shi X,Song GQ,Jiang XM,Huang XX,Weng SQ,Dong L,Shen XZ,Huang YQ,Zhu JM, 1210. To this end, many vectors have been developed in which the endogenous viral envelope proteins have been replaced by either envelope proteins from other viruses, or by chimeric proteins. Electrospun magnetic poly(l-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized Fe3O4 nanoparticles. MEHP promotes the proliferation of oral cancer cells via down regulation of miR-27b-5p and miR-372-5p. (IF 2.984) 504. MicroRNA-582-5p suppresses non-small cell lung cancer cells growth and invasion via downregulating NOTCH1. Wu L,Zhu X,Song Z,Chen D,Guo M,Liang J,Ding D,Wang W,Yan D. 1024. Overexpression of TRIM26 suppresses the proliferation, metastasis, and glycolysis in papillary thyroid carcinoma cells. Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells. Chuanlong Jia, Yongzhou Lu, Bo Bib, Liang Chena, Qingjian Yanga, Ping Yanga, Yu Guoa, Jingjing Zhua, Ningwen Zhuc and Tianyi Liu . Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1. Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction. Xin Chen,Deheng Li,Lei Chen,Bin Hao,Yang Gao,Liangdong Li,Changshuai Zhou,Xiayun He,Yiqun Cao, 1466. Zhang J, Wang M, Zhang Z, Luo Z, Liu F, Liu J. 74. Linc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression. In either case, entry into potential host cells requires a favorable interaction between a protein on the surface of the virus and a protein on the surface of the cell. Meng LW,Yuan GR,Lu XP,Jing TX,Zheng LS,Yong HX,Wang JJ, 762. MT1MMP promotes the proliferation and invasion of gastric carcinoma cells via regulating vimentin and Ecadherin. Ying Zhang,Zebiao Zhang,Wanling Huang,Jinbiao Zeng, 1462. Zhao L,Shou H,Chen L,Gao W,Fang C,Zhang P, 761. Yang J,Yu F,Guan J,Wang T,Liu C,Wang Y,Liu G,Zhu S, 950. Exp Ther Med Gene. Zhang Y,Zhou X,Cheng L,Wang X,Zhang Q,Zhang Y,Sun S, 895. Sang Y,Zhang R,Sun L,Chen KK,Li SW,Xiong L,Peng Y,Zeng L,Huang G, 547. 211. Cai C,He H,Duan X,Wu W,Mai Z,Zhang T,Fan J,Deng T,Zhong W,Liu Y,Zhong W,Zeng G, 375. Long non-coding RNA AGAP2-AS1 exerts oncogenic properties in glioblastoma by epigenetically silencing TFPI2 through EZH2 and LSD1. Zhang J,Mao W,Dai Y,Qian C,Dong Y,Chen Z,Meng L,Jiang Z,Huang T,Hu J,Luo P,Korner H,Jiang Y,Ying S, 783. Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood mononuclear cells frompatients with atopic dermatitis. Yahui Li,Boli Hu,Gang Ji,Yina Zhang,Chenyang Xu,Jing Lei,Chan Ding,Jiyong Zhou, 1478. Liqiang Chen,Qingli Zhu,Lingwei Lu,Yanshan Liu, 1499. 257. . 141. Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling. An additional consideration relates to the biology of the single-stranded AAV-delivered transgenes. Xia P, Chen HY, Chen SF, Wang L, Strappe PM, Yang HL, Zhou CH, Zhang X, Zhang YX, Ma LL, Wang L. 238. 1,25-dihydroxyvitamin D3 attenuates oxidative stress-induced damage in human trabecular meshwork cells by inhibiting TGF-SMAD3-VDR pathway. Xiao-Xiao Ni,Jing Nie,Qiu-You Xie,Rong-Hao Yu,Lei Su,Zhi-Feng Liu, 1481. Classical Swine Fever Virus Infection and Its NS4A Protein Expression Induce IL-8 Production through MAVS Signaling Pathway in Swine Umbilical Vein Endothelial Cells. If the mutant gene(s) could be fixed, or if the expression of overactive/underactive genes could be normalized, the disease could be treated at the molecular level, and, in best case scenarios, potentially be cured. Mei PJ,Bai J,Miao FA,Li ZL,Chen C,Zheng JN,Fan YC, 471. McCarty DM. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo. Zhu H, Zhu X, Cheng G, Zhou M, Lou W. 201. Vitamin C mitigates heat damage by reducing oxidative stress, inducing HSP expression in TM4 Sertoli cells. Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling. Bai J, Yong HM, Chen FF, Mei PJ, Liu H, Li C, Pan ZQ, Wu YP, Zheng JN. Silk fibroin coating through EDC/NHS crosslink is an effective method to promote graft remodeling of a polyethylene terephthalate artificial ligament. Up-Regulating the expression of VEGF in vitro inhibits iron-uptake stimulated osteoclast differentiation by electron... Inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs Signaling in mice 3,3'-Diindolylmethane. 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