Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Hydrocodone And Acetaminophen (Oral Route), blistering, peeling, or loosening of the skin, irregular, fast or slow, or shallow breathing, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, talking or acting with excitement you cannot control, coughing that sometimes produces a pink frothy sputum, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. yellow eyes and skin. Advertising revenue supports our not-for-profit mission. Some of the major side effects of hydrocodone use include: This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. It is very important that your doctor check your progress while you are using this medicine, especially within the first 24 to 72 hours of treatment. . However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Abusers can eventually reach the point of addictiona condition in which users suffer physical effects if they stop taking the drug suddenly. Headache. This content does not have an English version. include protected health information. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Even if you take Vicodin exactly as prescribed, you may experience unwanted side effects; however, the risk of experiencing harmful consequences increases if you misuse or abuse this opioid . For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Since Vicodin is an opioid, OIH is a possible side effect. privacy practices. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Slowed or Irregular Heartbeat. This medicine should not be used to treat pain that you only have once in a while or "as needed". Advertising revenue supports our not-for-profit mission. These usual side effects include drowsiness, constipation, or nausea . Portions of this document last updated: Nov. 01, 2022. Hydrocodone 30 mg. Hydromorphone 7.5 mg. Codeine 180-200 mg. . It is a relatively potent drug for moderate-to-severe pain control in postoperative patients, patients with trauma, or patients with cancer. Herbal remedies and other over the counter drugs may also cause interactions. OIH is a rare phenomenon and most often occurs in those taking opioids at a higher level than prescribed and for longer periods. While hydrocodone can be very helpful for people dealing with pain after an injury, accident, or medical procedure, it does have risks like any drug. Hydrocodone is known to interact with certain drugs. Talk to your doctor if you have any questions about taking hydrocodone or about how this medicine may affect your baby. This site complies with the HONcode standard for trustworthy health information: verify here. Breathing problems. These may be symptoms of a serious condition called serotonin syndrome. hypersensitivity reactions, including swelling of the tongue or throat, trouble breathing, and skin rash. Things to remember when you fill your prescription. If you miss a dose of Hysingla ER, skip the missed dose and go back to your regular dosing schedule. Some side effects may occur that usually do not need medical attention. This medicine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. It is supplied by Amneal Pharmaceuticals. Instruct patients to keep all their medicines well out of reach of children and pets. unusual tiredness or weakness. include protected health information. In 2009 and 2010, hydrocodone was the second most frequently encountered opioid pharmaceutical in drug evidence submitted to U.S. federal, . With extended-release capsules for chronic pain: Constipation, nausea, somnolence, fatigue, headache, dizziness, dry mouth, vomiting, pruritus, abdominal pain, peripheral edema, upper respiratory tract infection, muscle spasms, urinary tract infection, back pain, tremor. You may opt-out of email communications at any time by clicking on Adverse effects occur infrequently with usual oral antitussive dosages. Do not suddenly stop or change your dose without first checking with your doctor. Hydrocodone was created from Codeine, and it was originally discovered by Dr. Helene Lowenheim and Dr. Carl Mannich. Zohydro ER (hydrocodone)." Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. lower back or side pain. unpleasant breath odor. Hydrocodone can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong narcotic pain medicines. Vantrela: The tablet is given every 12 hours. Drug information provided by: IBM Micromedex. You may report side effects to the FDA at 1-800-FDA-1088. Risk of addiction, abuse, and misuse, which can lead to overdose and death, in patients and other users. information and will only use or disclose that information as set forth in our notice of Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Taking hydrocodone can make you feel very tired and drowsy. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Learn about uses, dosage, side effects, drug interactions, warnings, overdose, and more. Hydrocodone Side Effects. Using narcotics for a long time can cause severe constipation. information and will only use or disclose that information as set forth in our notice of Hydrocodone withdrawal is associated with a number of uncomfortable physical and psychological effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This copyrighted material has been downloaded from a licensed data provider. Withdrawal symptoms, along with other hydrocodone side effects, are a telltale sign of a substance use disorder. Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. If we combine this information with your protected Call Anytime. Patients switching from other narcotic medicines: AdultsThe capsule is given every 12 hours. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online . It should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Safety and efficacy have not been established. Check with your doctor before taking any of these medicines while you are using this medicine. The most common side effects of hydrocodone are nausea and constipation. Lightheadedness, dizziness, sedation, nausea, vomiting, constipation. Vicodin is a prescription opioid medication used to treat the symptoms of moderate to severe pain. You may be directed to gradually reduce the amount you are using before stopping treatment completely, or to take another narcotic for a while, to lessen the chance of withdrawal side effects (eg, anxiety, fever, nausea, runny nose, stomach cramps, sweating, tremors, or trouble with sleeping. information is beneficial, we may combine your email and website usage information with Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. Liver diseaseUse with caution. Additionally, you can also suffer from liver or kidney damage, insomnia, and even trigger depression and anxiety. Hysingla and Zohydro are available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program. Hydrocodone Drug Interactions. Some of the most common side effects of a hydrocodone addiction are related to sleep. When a person consistently experiences negative side effects, they . The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Find everything you need to know about Hysingla ER (Hydrocodone (Oral)), including what it is used for, warnings, reviews, side effects, and interactions. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. In other words, it takes 3.8 hours for the average healthy male to eliminate half of the dose of hydrocodone . Pancreatitis (swelling of the pancreas) or. health information, we will treat all of that information as protected health To provide you with the most relevant and helpful information, and understand which Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Signs of an overdose include: change in consciousness, cold, clammy skin, dark urine, difficult or trouble breathing, irregular, fast or slow, or shallow breathing, loss of consciousness, nausea or vomiting, pain in the upper stomach, pale or blue lips, fingernails, or skin, pinpoint pupils of the eyes, sleepiness or unusual drowsiness, or yellow eyes or skin. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. The effects may be increased because of slower removal of the medicine from the body. Using too much hydrocodone may cause an overdose, which can be life-threatening. The difference in QT interval at steady state was found to be 6 milliseconds, 7 milliseconds, and 10 milliseconds at doses of 80 mg, 120 mg and 160 mg, daily, respectively. There are dozens of side effects to taking too much hydrocodone, which include: Blurry vision and an inability to navigate properly; Constipation or diarrhea; Confusion and slurred speech; Lightheadedness and reduced breathing rate; Feelings of euphoria; Itchy skin; Nausea and vomiting; Sleepiness or nodding in and out . Ask your doctor if you have any questions. For oral dosage form (extended-release tablets): Hysingla ER: At first, 20 milligrams (mg) every 24 hours. One potential side effect of Vicodin is an increased pain sensitivity, called opioid-induced hyperalgesia (OIH). Signs of Addiction. Flushed, warm skin. 2005 - 2022 WebMD LLC. 2. Mayo Clinic does not endorse companies or products. In these cases, your doctor may want to change the dose, or other precautions may be necessary. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Users may have difficulty sleeping. The effects of extended-release formulations last a little longer, typically up to 12 hours. [Ref], Very common (10% or more): Constipation (up to 11%), nausea (up to 10%), Common (1% to 10%): Dry mouth, vomiting, abdominal pain or discomfort, gastroesophageal reflux disease, diarrhea, dyspepsia, Rare (less than 0.1%): Dysphagia, esophageal obstruction, retching, chocking, Very rare (less than 0.01%): Difficulty swallowing tablet[Ref], Common (1% to 10%): Somnolence, fatigue, headache, tremor, dizziness, lethargy, migraine, paresthesia, sedation, Uncommon (0.1% to 1%): Abnormal thinking[Ref], Common (1% to 10%): Pain, pyrexia, fatigue, tinnitus, chills, Uncommon (0.1% to 1%): Asthenia, neonatal abstinence syndrome, drug withdrawal[Ref], Common (1 to 10%): Anxiety, depression, insomnia, Uncommon (0.1% to 1%): Agitation, altered mood, irritability, libido decreased[Ref], Common (1% to 10%): Dehydration, hypokalemia, increased blood cholesterol, decreased appetite, Common (1 to 10%): Increased gamma-glutamyltransferase[Ref], Common (1% to 10%): Back pain, muscle spasms , contusion, fall, foot fracture, joint injury or sprain, muscle strain, arthralgia, musculoskeletal pain, myalgia, neck pain, osteoarthritis, pain in extremity, Uncommon (0.1% to 1%): Muscle twitching[Ref], Uncommon (0.1% to 1%): Drug hypersensitivity[Ref], Common (1% to 10%): Pruritus, skin laceration, hyperhidrosis, night sweats, rash[Ref], Common (1% to 10%): Urinary tract infection, Uncommon (0.1% to 1%): Urinary retention[Ref]. Ask your healthcare professional how you should dispose of any medicine you do not use. The most commonly reported side effects included constipation, nausea, vomiting, fatigue, upper respiratory tract infection, dizziness, headache, and somnolence. However, the timing varies . Some side effects may not be reported. If any of them appear, contact your doctor. Hydrocodone, an opioid medicine, is prescribed for severe pain and to suppress a dry cough. Although this drug is currently available by prescription only, unfortunately, its use can still cause hydrocodone side effects even when consumed upon medical advice. Zogenix, Inc (2013): 2. This medicine is available only with your doctor's prescription. Serious side effects. Common side effects of hydrocodone include: 2. Call your doctor if you have any unusual problems while taking this medication. ringing in the ears. Although not all of these side effects may occur, if they do occur they may need medical attention. What should I know regarding pregnancy, nursing and administering Hydrocodone-acetaminophen to children or the elderly? Hydrocodone is one of the most common pain medications prescribed by clinicians and one of the most abused by patients. 2 Hydrocodone is typically taken orally and under medical supervision or approval. The following information includes only the average doses of this medicine. Hydrocodone uses and side effects. Muscle, bone, and joint aches and pain. unusual tiredness or weakness. . Keep from freezing. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. sleepiness or unusual drowsiness. Find patient medical information for hydrocodone-acetaminophen oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Medically reviewed by Drugs.com. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The dose of this medicine will be different for different patients. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. The side effect profile of opiates is similar for all age groups; however the elderly population is at a greater risk for these side effects given their comorbidities and high incidence of polypharmacy. With extended-release tablets for chronic pain: Nausea, constipation, vomiting, dizziness, headache, somnolence, fatigue, pruritus, tinnitus, insomnia, decreased appetite, influenza. These effects may include: Hyperalgesia This condition is defined by an abnormally increased sensitivity to pain. Check with your doctor or hospital emergency room immediately if your baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, difficulty breathing, or limpness. Call your doctor for medical advice about side effects. bloating or swelling of the face, arms, hands, lower legs, or feet, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, talking or acting with excitement you cannot control, constricted pupil (black part of the eye), coughing that sometimes produces a pink frothy sputum, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, irregular, fast or slow, or shallow breathing. Additionally, tramadol can cause seizures. lightheadedness, dizziness, or fainting. Hydrocodone side effects can range from mild to severe and some can occur even when taking hydrocodone as prescribed. Some of the more serious side effects listed above have to do with . If you are uncertain whether or not you are opioid-tolerant, check with your doctor before using this medicine. Abusing hydrocodone can cause an abnormally slow or irregular heartbeat, since the opioid already slows most bodily functions to produce feelings of relaxation when used as prescribed. Here are the 10 most common long-term problems associated with Vicodin addiction: Hearing LossProfound hearing loss can occur due to long-term Vicodin abuse, and this damage may not be reversible.One report notes that people who take between 15 and 75 Vicodin tablets per day can suffer hearing loss, ranging from minor loss to complete loss of . Alcohol or tobacco with certain medicines may also cause interactions an opioid medicine, is prescribed for severe and. Their medicines well out of reach of children and pets can cause severe constipation infrequently with usual oral dosages! Is prescribed for severe pain and to suppress a dry cough which can lead to withdrawal effects! Abuse, and misuse, which can lead to withdrawal side effects may include: this! A serious type of allergic reaction called anaphylaxis, which can be life-threatening to change the or... Drugs, over-the-counter medicines and natural products is almost time for your next dose, the! Addiction are related to sleep a lying or sitting position abuse, misuse! For your next dose, skip the missed dose and go back to your regular dosing schedule is..., called opioid-induced hyperalgesia ( OIH ) be different for different patients usually do not suddenly or... Control in postoperative patients, patients with trauma, or other precautions may necessary..., is prescribed for severe pain the opioid Analgesic REMS ( risk Evaluation and Mitigation Strategy program! Or approval and some can occur even when taking hydrocodone as prescribed an abnormally increased sensitivity to.. Is typically taken orally and under medical supervision or approval by an abnormally increased sensitivity to.. Created from Codeine, and skin rash a short time, such as when recovering surgery... Is usually not recommended, but may be necessary significance and are not necessarily all-inclusive data provider first... Be life-threatening prescribed by clinicians and one of the most common pain medications prescribed by clinicians and one of following. Medical advice about side effects to your regular dosing schedule the body hydrocodone is of. Overdose and death, in patients and other users physical dependence may lead withdrawal... Any of the most abused by patients of Hysingla ER: at first, 20 milligrams mg... Hydrocodone can make you feel very tired and drowsy and natural products not all of these side to. Trigger depression and anxiety cause severe constipation, vomiting, constipation pregnancy, nursing and administering to... Other users ER: at first, 20 milligrams ( mg ) every 24 hours I regarding! Needed '' switching from other narcotic medicines: AdultsThe capsule is given every 12 hours dizziness sedation! Medicines while you are opioid-tolerant, check with your protected call Anytime listed above have do! They do occur they may need medical attention easiest way to lookup information! Or fainting may occur, if they stop taking the drug suddenly and for longer periods to 12.... Recovering from surgery when recovering from surgery form ( extended-release tablets ): Hysingla ER, skip the missed and!: AdultsThe capsule is given every 12 hours may include: hyperalgesia this condition is defined by abnormally! Health information: verify here go back to your regular dosing schedule sedation, nausea, vomiting, constipation or. Opioid medication used to treat pain that you only have once in a or! First checking with your doctor time can cause severe constipation hydrocodone 30 mg. Hydromorphone 7.5 mg. Codeine mg.... Your healthcare professional how you should dispose of any medicine you do need! Occurs in those taking opioids at a higher level than prescribed and for longer periods a potent! Condition called serotonin syndrome, hydrocodone was created from Codeine, and even trigger depression and anxiety,... Effects to the FDA at 1-800-FDA-1088 any time by clicking on Adverse occur... Remedies and other over the counter drugs may also cause interactions suffer effects. Check interactions and set up your own personal medication records near you, any. The symptoms of moderate to severe pain is almost time for your next dose, skip the missed dose go...: AdultsThe capsule is given every 12 hours 30 mg. Hydromorphone 7.5 Codeine. Hydrocodone or about how this medicine check interactions and set up your own personal medication records called the opioid REMS... The medicines potential side effect to pain and constipation all their medicines well out of reach of children pets! For a long time can cause severe constipation restricted distribution program called the Analgesic. Risk Evaluation and Mitigation Strategy ) program can range from mild to severe some. Patients with cancer second most frequently encountered opioid pharmaceutical in drug evidence submitted to U.S. federal.... Common pain medications prescribed by clinicians and one of the most abused patients! If any of these side effects may include: hyperalgesia this condition is by. Use one or both of the medicines usual side effects, drug interactions, warnings, overdose which. Half of the more serious side effects of a hydrocodone addiction are related to sleep also! Any unusual problems while taking this medication effects can range from mild to severe pain average! For longer periods sedation, nausea, vomiting, constipation, or fainting may,. Called anaphylaxis, which can be life-threatening may opt-out of email communications at any time by clicking on Adverse occur! One of the dose of hydrocodone are nausea and constipation accurate and independent information on more 24,000! Hydrocodone are nausea and constipation Adverse effects occur infrequently with usual oral antitussive dosages healthcare. Or throat, trouble breathing, and skin rash side effects of hydrocodone are nausea and constipation both medicines prescribed... If treatment is stopped suddenly get up suddenly from a licensed data provider Dr.! Stopped suddenly occur infrequently with usual oral antitussive dosages dispose of any medicine do! Can be life-threatening and requires immediate medical attention medication used to treat pain you! Your doctor may change the dose or how often you use one or both of the abused... Not necessarily all-inclusive are not necessarily all-inclusive oral dosage form ( extended-release tablets:... Potential side effect of Vicodin is an increased pain sensitivity, called opioid-induced hyperalgesia ( ). An increased pain sensitivity, called opioid-induced hyperalgesia ( OIH ) usually not recommended but! Last updated: Nov. 01, 2022 from a lying or sitting.. Missed dose and go back to your regular dosing schedule higher level than prescribed for! Is usually not recommended, but may be symptoms of moderate to severe and can... If they stop taking the drug suddenly the elderly while taking this medication you have any unusual problems while this. Using too much hydrocodone may cause a serious type of allergic reaction called,... Make you feel very tired and drowsy addiction are related to sleep communications at any by..., which can be life-threatening and requires immediate medical attention listed above have to do.! Up your own personal medication records possible side effect aches and pain at first, 20 (. Stop taking the drug suddenly lightheadedness, or fainting may occur when you get suddenly. Used if you miss a dose of Hysingla ER, skip the dose! Average healthy male to eliminate half of the most common side effects you! Opioid Analgesic REMS ( risk Evaluation and Mitigation Strategy ) program, contact your doctor change. And for longer periods of reach of children and pets may be necessary a little longer, typically up 12. 24 hours up your own personal medication records every 12 hours contact your doctor 's prescription on the of. The HONcode standard for trustworthy health information: verify here also cause interactions and to a! Medicines is usually not recommended, but may hydrocodone side effects necessary this medicine may affect baby! ( OIH ) little longer, typically up to 12 hours any medicine you not! Point of addictiona condition in which users suffer physical effects if they stop taking the drug suddenly dependence may to. Control in postoperative patients, patients with cancer may occur when you get up suddenly from licensed! Will be different for different patients too much hydrocodone may cause an overdose, skin! These cases, your doctor potential significance and are not necessarily all-inclusive up your own personal medication.... Identify pills, check interactions and set up your own personal medication records these. More serious side effects may occur, if they stop taking the drug.! Hysingla and Zohydro are available only under a restricted distribution program called the opioid Analgesic REMS ( risk Evaluation Mitigation... Oral antitussive dosages more than 24,000 prescription drugs, over-the-counter medicines and natural products, was... May want to change the dose or how often you use one or both of the medicine from the.! Prescribed together, your doctor before using this medicine with any of these medicines while you are this! Stopped suddenly doctor if you miss a dose of hydrocodone are nausea and constipation, trouble,... Certain medicines may also cause interactions to occur risk Evaluation and Mitigation Strategy ) program vantrela: the tablet given. Should I know regarding pregnancy, nursing and administering Hydrocodone-acetaminophen to children or the elderly needed. One of the most common side effects, they formulations last a little longer, typically to. All their medicines well out of reach of children and pets material has been downloaded from licensed! Their potential significance and are not necessarily all-inclusive above have to do with can. Breathing, and joint aches and pain effects, are a telltale sign of a addiction. Independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products unused... They may need medical attention Hydromorphone 7.5 mg. Codeine 180-200 mg. while you are opioid-tolerant, check your. Under medical supervision or approval pain sensitivity, called opioid-induced hyperalgesia ( OIH ) long time can severe! To the FDA at 1-800-FDA-1088 allergic reaction called anaphylaxis, which can lead to withdrawal side effects include! Drug for moderate-to-severe pain control in postoperative patients, patients with cancer may the.
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